Posit Science Corporation (BrainHQ)

Posit Science Corporation is an American applied neuroscience company dedicated to enhancing human performance and promoting brain health through scientifically validated brain training software and services. Founded in 2002 as Neuroscience Solutions Corporation and renamed in 2005, the company is headquartered in San Francisco, California. Its mission is to be a leading provider of programs that apply breakthroughs in brain research to improve cognitive function.

The company's flagship product is BrainHQ, an online platform offering a suite of adaptive, personalized brain training exercises. These exercises are designed to improve various cognitive abilities, including memory, attention, brain speed, people skills, decision-making, and navigation. BrainHQ is available directly to consumers and through strategic partnerships with health insurers (including Medicare Advantage plans), military organizations, libraries, sports programs, and research institutions.

Under the leadership of CEO Henry Mahncke and co-founder and Chief Scientific Officer Dr. Michael Merzenich, Posit Science emphasizes a rigorous scientific approach. In 2025, a significant NIH-funded study, conducted in collaboration with McGill University, demonstrated that BrainHQ exercises could significantly upregulate the production of acetylcholine, a key brain chemical, in older adults, suggesting a reversal of cognitive aging equivalent to approximately a decade of rejuvenation. This contributed to a record-breaking 70 peer-reviewed publications for BrainHQ in 2025, further solidifying its position as a leader in evidence-based cognitive training.