Pacific Biosciences of California, Inc.

Pacific Biosciences of California, Inc., commonly known as PacBio, is an American biotechnology company established in 2004. Headquartered in Menlo Park, California, its core business involves developing and manufacturing advanced systems for gene sequencing and real-time biological observation. The company's mission is to enable the promise of genomics to better human health by providing comprehensive genomic insights.

PacBio's key offerings include sequencing systems such as the Revio, Vega, Sequel Systems (Sequel II and IIe), and Onso, which are powered by its proprietary Single-Molecule Real-Time (SMRT) sequencing technology. This technology delivers highly accurate long reads, known as HiFi sequencing, and also incorporates Sequencing by Binding (SBB) technology for short reads. The company provides consumables, software like SMRT Link, and comprehensive support services. PacBio's solutions cater to diverse market segments, including human health (e.g., rare diseases, oncology), plant and animal sciences, infectious disease research, and biopharmaceutical development.

Under the leadership of President & CEO Christian Henry and Chairman of the Board John F. Milligan, PacBio continues to advance its market position. Recent strategic moves include the sale of short-read sequencing assets in January 2026 to sharpen its focus on long-read sequencing. The company has also engaged in notable partnerships, such as collaborations with Lucid Genomics for tertiary analysis, Covaris for workflows enabling HiFi sequencing of FFPE tumor samples, and Basecamp Research for the Trillion Gene Atlas Initiative. Additionally, PacBio joined the iHope initiative in early 2026 to expand access to genetic testing for rare diseases and appointed Chris Gibson to its Board of Directors in March 2026, bringing expertise in AI-driven biology. The company reported a 14% year-over-year revenue growth in Q4 2025, reflecting its ongoing efforts to improve commercial execution and expand its product offerings.